Erimos has conducted multiple phase I clinical trials with terameprocol at various top tier institutions and clinical trial sites in the U.S. Erimos’ primary clinical focus has been the evaluation of terameprocol administered intravenously to patients with various forms of cancer.
These trials include:
EM-1421 #101: Open-Label Phase I Dose Escalation Study of Intravenous Infusion of Tetra-o-Methyl Nordihydroguaiaretic Acid (EM-1421) in Subjects with Refractory Malignant Tumors. Results from this study were presented at the 2007 American Society of Clinical Oncology meeting and the 2007 American Association for Cancer Research meeting.
EM-1421 #104: Phase I continuous intravenous infusion study of Terameprocol (EM-1421) in subjects with refractory solid tumors.
EM-1421 #105: Phase I Study of Terameprocol (EM-1421), a Survivin and Cyclin-Dependent-Kinase-1 (Cdc2) Inhibitor, in Patients with Leukemia.
EM-1421 #103: Open-Label Phase I/ Phase II Study of Intravenous Infusion of Tetra-o-Methyl Nordihydroguaiaretic Acid (EM-1421) in Subjects with Recurrent High Grade Glioma. This clinical trial was conducted in concert with the New Approaches to Brain Tumor Therapy Consortium (NABTT).
Results from these Phase I intravenous trials are encouraging and Phase II studies are being planned.
Terameprocol has also been evaluated in a Phase I/II clinical pilot study for use as an intravaginal therapy for the treatment of Cervical Intraepithelial Neoplasia (CIN), a viral-induced (human papilloma virus) pre-cancerous change in the cervix. The pilot clinical study demonstrated encouraging results for this indication.
Erimos has additionally completed a Phase I study of intralesionalterameprocol in refractory head and neck cancer.